Forskolix™ is extracted and standardised by Coleus forskolin roots. Coleus forskohlii, a plant used in traditional medicine, contains a compound called Forskolin, which is thought to have various effects on metabolism and glucose regulation. Forskolin has an efficacy of lowering blood pressure, improving blood circulation and heart function and helps in reducing respiratory tract infections, cough and restlessness. Also, Forskolin is used in stinging of the eyes and enlarging of blood vessels in the eyes. Coleus extract improved insulin sensitivity in people with Type 2 diabetes.
Recommended Daily Dose: 500 mg x 2 C/Day
Anti-diabetic, Weight management, helps in the treatment of Congestive heart function, treatment of hypertrophic cardiomyopathy.
Activation of Adenylyl Cyclase (cAMP Pathway): Forskolin activates an enzyme called adenylyl cyclase, which increases levels of cyclic AMP (cAMP) in cells. This can have several effects, including promoting the activity of protein kinase A (PKA), which influences various metabolic processes, including glucose metabolism and modulates various cardiovascular functions. Insulin Sensitivity: Some studies suggest that forskolin may help increase insulin sensitivity by improving the function of insulin receptors and the effectiveness of insulin signalling. This could potentially help reduce insulin resistance, a key factor in type 2 diabetes. Increased Lipolysis: Forskolin may also promote the breakdown of fats (lipolysis), which could help improve insulin sensitivity. When fat cells are reduced or more efficiently utilized, insulin becomes more effective in regulating blood sugar levels.
Pre-clinical studies were conducted for Forskolix™ in comparison to normal Coleus extract at PRADO Pune. The objective of this study is to evaluate the efficacy of Forskolix™ in Streptozotocin induced diabetes in Sprague Dawley Rats when administered by Oral route. The animals were kept for overnight fasting for approximately 14-16 hours. The streptozotocin (60 mg/kg IP) was injected by intraperitoneal route as a single dose on day 1 to induce diabetes. Animals will be screened for development of hyperglycaemia (fasting blood glucose >250 mg/kg) for 5 days after streptozotocin injection. The dose volume will not be exceeding 10 ml/kg body weight and actual volume to be administered were calculated based on the body weights of each animal.
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